The research of MUSIC is focused at “Functional Imaging using Ultrasound”. The deformation of tissues as well as the perfusion of organs and tissues are important parameters to assess the function. The deformation of tissues can be quantified with high spatial as well as temporal resolution using Ultrasound Strain Imaging.

The deformation of tissues can be a result of the function of the organ (pumping heart, contraction of a muscle) or can be the result of a force that is applied on the tissue under interrogation (blood pressure on the arterial wall, user controlled tissue deformation of the breast).

In case of user controlled deformation, this technique is called elastography. At MUSIC, this technique is applied on arteries for vulnerable plaque detection and on breast to detect tumors and guide therapeutic interventions. Strain imaging techniques are primarily geared towards deformation of the heart and muscle as a figure of merit for its function.

Carotid Imaging

Cardiovascular disease is one of the leading causes of death in the Western World. In the Netherlands 20.000 people die each year of an acute myocardial infarction or stroke. Plaque rupture in the carotid artery is the source of most strokes and ischemic attacks. Therefore, we develop methods to determine the elastic properties of carotid plaques in order to identify the vulnerable plaque. Since blood flow is representative for the function of the arteries and is also an important predictor for the risk of developing plaques, we are also developing new techniques to image the blood velocity is the carotid artery. more...

Cardiac Imaging

This project aims at assessment of the geometry, composition and function of the heart. It is a continuation of the research that MUSIC performed to stage the state of the myocardium in children that are born with a congenital heart disease. Currently, the project focuses on accurate assessment of the deformation and geometry of the heart and the blood flow patterns in the left ventricle using ultrafast ultrasound imaging techniques. The project is financed by a VICI grant of NWO and STW. more...

Ultrasound imaging of muscle dynamics

We can use ultrasound techniques to quantify tissue deformation. Quantification of tissue deformations can assist clinicians in judging pathologies and can be used to validate and improve biomechanical models. In this project we aim to develop 3D ultrasound diagnostic and evaluation tools to quantify the degenerative status of orthopaedic patients. more...

Liver fat content quantification

In modern society (Non) Alcoholic Fatty Liver Diseases (NAFLD), and obesity are growing problems. The liver is able to store lipids which is a reversible process. The storage of too much lipids however may cause inflammatory reactions which may results in liver fibrosis. The primary goal of this project is to develop a non-invasive screening tool for quantification/staging of the liver fat content using quantitative ultrasound B-mode parameters. more...

Breast cancer detection

Early detection of breast cancer through screening and subsequent treatment improves outcome. However, current diagnostic methods are insufficient to detect all breast cancers in time. Ultrasound imaging might be an excellent choice for early cancer detection and monitoring treatment in women with dense breast tissue as it has low costs, is real-time en does not use hazardous radiation. We will develop new ultrafast 3D elastography techniques to improve specificity and clinical applicability of 3D Automated Breast Volume Scanning (ABVS). more...

Quality Assurance 4 UltraSound (QA4US)

MUSIC developed a Quality Assurance program 4 UltraSound equipment (QA4US TM). Based on theoretical considerations, a minimum set of parameters to determine the quality of an ultrasound machine is derived. Regularly, a course for Medical Physicists and Hospital Technicians is organised to explain the underlying prinicple and make people familiar with the software. more...

Fetal lung maturity estimation

MUSIC together with Gynaecology explore the applicablilty of the CAUS engine for fetal lung maturity prediction, further called: Non-invasie Multiparametric UltraSound (NIMPU) more...